Adrenocorticotropin and catecholamines are the primary messengers secreted from the neuroendocrine system when mollusks are disturbed by stressors. The former induces the secretion of the latter. Both circulation nor adrenaline and dopamine concentrations increase in response to stressors, such as those from mechanical stressors, variations of temperature an salinity and some parasites. Noradrenaline concentrationsvaryfrom 1ng/mlto20 ng/ml, anddopamine concentrations vary from 0.4 ng/ml to3 ng/ml. Inturn, the change of catecholamines induces a series of responses, such as increased oxygen uptake and reallocation of energy. Stressors induce the changes of some immune parameters including the numbers of hemocytes, the hemocyte migratory activity, phagocytotic activity, the circulation catecholamine concentrations, chemilum inesence and superoxide anion production. Studies on the effect of stress on mollusks immune functions are rare. Stressors can exert inhibiting effects on the mollusks immune functions, and subsequently a stimulating effect takes place. In this paper, stress induced neuroendocrine and immune responses in mollusks are reviewed.