Phycocyanin is one of the main active compounds present in cyanobacteria. It has multiple functions, such as scavenging oxygen free radicals, and it has anti-aging and anti-allergy properties that are manifested in combination with a variety of amino acids. In order to study the feasibility of using phycocyanin in the cosmetics industry, we consider the New Zealand rabbits as the model animal and conduct experiments such as light toxicity, acute dermal toxicity, and skin allergy tests to verify its toxic effects on the skin of the rabbit. The results show no obvious toxicity and no allergic reactions to the skin of the rabbits. These results provide a reference for the application of phycocyanin in the fields of cosmetology and makeup.