China is leading in the scale and production of mariculture worldwide. Seawater mollusks accounted for the majority of the total mariculture production in China. The molluscan mariculture industry has seen notable achievement in both technique R D and its application. This paper presents the advance in the aspects of breeding, ecological aquaculture, processing, and analyses the challenges arise from the industry, as well as the technique development trend. This review is aimed to provide with a reference in order to promote the sustainable development of molluscan mariculture.