As a clean and rich energy source,natural gas hydrate has become a focus of study in the world.In this paper,the geologic condition of hydrate reservoir is analyzed. Combining with the natural gas hydrate drilling characteristics and drilling accidents,prevention and response methods are discussed.It is proposed that to restrain and control natural gas hydrate decomposition is the key to safety drilling,in which a reasonable choice of drilling fluid system is important.Some performance parameters should be taken into account in the selection of drilling fluid.The basic parameters requirements of natural gas hydrate drilling are also analyzed.